“Atypical” atypical parkinsonism: Critical appraisal of a cohort

Atypical parkinsonism: an update

PURPOSE OF REVIEW This update discusses novel aspects on genetics, diagnosis, and treatments of atypical parkinsonism published over the past 2 years. RECENT FINDINGS A genome-wide association study identified new genetic risk factors for progressive supranuclear palsy and new genetic conditions presenting with atypical parkinsonism have been described. The clinical criteria for diagnosis of ...

Atypical antipsychotics and parkinsonism.

BACKGROUND Atypical antipsychotic agents are thought to be less likely than older typical agents to produce parkinsonism. This has not been well documented. We compared the risk of development of incident parkinsonism among older adults dispensed atypical relative to typical antipsychotics. METHODS Retrospective cohort study of all adults 66 years and older in Ontario. We used Cox proportiona...

Critical appraisal of eculizumab for atypical hemolytic uremic syndrome.

The biology of atypical hemolytic uremic syndrome has been shown to involve inability to limit activation of the alternative complement pathway, with subsequent damage to systemic endothelial beds and the vasculature, resulting in the prototypic findings of a thrombotic microangiopathy. Central to this process is the formation of the terminal membrane attack complex C5b-9. Recently, application...

Genetics of Atypical Parkinsonism Implications for Nosology

Clinical features of dystonia in atypical parkinsonism.

BACKGROUND The association between Dystonia and Parkinson's disease (PD) has been well described especially for foot and hand dystonia. There is however few data on dystonic postures in patients with atypical parkinsonism. OBJECTIVE To evaluate the frequency and pattern of dystonia in a group of patients with atypical parkinsonism (multiple system atrophy - MSA, progressive supranuclear palsy...